In 1851, 33-year-old Jane Todd Crawford, of Wellington, Ohio, rode 60 miles on horseback to seek treatment for what turned out to be a huge ovarian tumor. Anesthesia wasn’t yet available, so she sang and recited psalms to calm herself during the 25-minute operation. The surgeon made a nine-inch incision and “took out 15 pounds of a dirty gelatinous-looking substance” before removing the rest of the tumor. She was up and about five days later, and 25 days later she got back on her horse and rode home. She lived another 50 years.